CPK Isoenzymes
Alternate Names : Creatine Kinase-Isoenzymes, Creatine Phosphokinase-Isoenzymes, CK-Isoenzymes
What do the test results mean?
If a disease process is taking place, the total amount of CPK will
be high, and the individual isoenzyme increases are used to determine what part
of the body is responsible for the increase in total CPK. For example, when a
heart attack occurs, the total CPK becomes high because of an increase in the
CPK-MB and CPK-MM isoenzymes. The normal total CPK level is roughly 25 to
175 units per liter. Normal values for each of the isoenzymes are as follows:
CPK-BB: 0% of the total CPK
CPK-MB: 0% to 6% of the total CPK
CPK-MM: 96% to 100% of the total CPK
Abnormally high levels of CPK-BB may sometimes be seen in the following:
lung damage from a blood clot
shock
after cardiopulmonary resuscitation
Abnormally high levels of CPK-MB may indicate the following:
heart attack
any other trauma to the heart, such as from heart surgery
electrical injuries
Abnormally high levels of CPK-MM may indicate the following:
heart attack
muscle damage
intramuscular injections
muscular dystrophy
myositis,
an inflammation in the muscles usually due to infection or immune system
disease
convulsions
recent surgery
rhabdomyolysis,
which is widespread muscle destruction, usually due to alcoholism or exercise
strenuous exercise
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