Angiotensin-converting Enzyme (ACE) Inhibitors (Systemic)
Category- Antihypertensive —Benazepril; Captopril; Cilazapril; Enalapril; Enalaprilat; Fosinopril; Lisinopril; Moexipril; Perindopril; Quinapril; Ramipril; Trandolapril
- Vasodilator, congestive heart failure—Benazepril; Captopril; Cilazapril; Enalapril; Fosinopril; Lisinopril; Quinapril; Ramipril; Trandolapril
Description ACE inhibitors belong to the class of medicines called high
blood pressure medicines (antihypertensives). They are used to treat high
blood pressure (hypertension).
High blood pressure adds to the workload of the heart and arteries. If
it continues for a long time, the heart and arteries may not function properly.
This can damage the blood vessels of the brain, heart, and kidneys, resulting
in a stroke, heart failure, or kidney failure. High blood pressure may also
increase the risk of heart attacks. These problems may be less likely to occur
if blood pressure is controlled.
Lisinopril, captopril, ramipril, and trandolapril are used in some patients
after a heart attack. After a heart attack, some of the heart muscle is damaged
and weakened. The heart muscle may continue to weaken as time goes by. This
makes it more difficult for the heart to pump blood. Lisinopril use may be
started within 24 hours after a heart attack to increase survival rate. Captopril,
ramipril, and trandolapril help slow down the further weakening of the heart.
Captopril is also used to treat kidney problems in some diabetic patients
who use insulin to control their diabetes. Over time, these kidney problems
may get worse. Captopril may help slow down the further worsening of kidney
problems.
In addition, some ACE inhibitors are used to treat congestive heart failure
or may be used for other conditions as determined by your doctor.
The exact way that these medicines work is not known. They block an enzyme
in the body that is necessary to produce a substance that causes blood vessels
to tighten. As a result, they relax blood vessels. This lowers blood pressure
and increases the supply of blood and oxygen to the heart.
These medicines are available only with your doctor's prescription, in
the following dosage forms:
Oral
-
Benazepril
-
Tablets (U.S. and Canada)
-
Captopril
-
Tablets (U.S. and Canada)
-
Cilazapril
-
Enalapril
-
Tablets (U.S. and Canada)
-
Fosinopril
-
Tablets (U.S. and Canada)
-
Lisinopril
-
Tablets (U.S. and Canada)
-
Moexipril
-
Perindopril
-
Tablets (U.S. and Canada)
-
Quinapril
-
Tablets (U.S. and Canada)
-
Ramipril
-
Capsules (U.S. and Canada)
-
Trandolapril
-
Tablets (U.S. and Canada)
Parenteral
-
Enalaprilat
-
Injection (U.S. and Canada)
Brand NamesSome commonly used brand names are:
In the U.S.—
- Accupril 10
- Aceon 9
- Altace 11
- Capoten 2
- Lotensin 1
- Mavik 12
- Monopril 6
- Prinivil 7
- Univasc 8
- Vasotec 4 5
- Zestril 7
In Canada—
- Accupril 10
- Altace 11
- Capoten 2
- Coversyl 9
- Inhibace 3
- Lotensin 1
- Mavik 12
- Monopril 6
- Prinivil 7
- Vasotec 4 5
- Zestril 7
|
Note:
|
For quick reference, the following angiotensin-converting enzyme
(ACE) inhibitors are numbered to match the corresponding brand names. |
| This information applies to the following medicines: |
| 1. |
Benazepril (ben-AY-ze-pril) |
| 2. |
Captopril (KAP-toe-pril) |
| 3. |
Cilazapril (sye-LAY-za-pril)* |
| 4. |
Enalapril (e-NAL-a-pril) |
| 5. |
Enalaprilat (e-NAL-a-pril-at) |
| 6. |
Fosinopril (foe-SIN-oh-pril) |
| 7. |
Lisinopril (lyse-IN-oh-pril) |
| 8. |
Moexipril (moe-EX-i-pril)† |
| 9. |
Perindopril (per-IN-doe-pril) |
| 10. |
Quinapril (KWIN-a-pril) |
| 11. |
Ramipril (ra-MI-pril) |
| 12. |
Trandolapril (tran-DOE-la-pril) |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
|
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