Beta-adrenergic Blocking Agents and Thiazide Diuretics (Systemic)
Category- Antihypertensive—Atenolol and Chlorthalidone; Bisprolol and Hydrochlorothiazide; Metoprolol
and Hydrochlorothiazide; Nadolol and Bendroflumethiazide; Pindolol and Hydrochlorothiazide; Propranolol and Hydrochlorothiazide; Timolol and Hydrochlorothiazide
DescriptionBeta-adrenergic blocking agent (more commonly,
beta-blockers) and thiazide diuretic combinations belong to the group of medicines
known as antihypertensives (high blood pressure medicine). Both ingredients
of the combination control high blood pressure, but they work in different
ways. Beta-blockers (atenolol, bisoprolol, metoprolol, nadolol, pindolol,
propranolol, and timolol) reduce the work load on the heart as well as having
other effects. Thiazide diuretics (bendroflumethiazide, chlorthalidone, and
hydrochlorothiazide) reduce the amount of fluid pressure in the body by increasing
the flow of urine.
High blood pressure adds to the work load of the heart and arteries. If
it continues for a long time, the heart and arteries may not function properly.
This can damage the blood vessels of the brain, heart, and kidneys, resulting
in a stroke, heart failure, or kidney failure. High blood pressure may also
increase the risk of heart attacks. These problems may be less likely to occur
if blood pressure is controlled.
Beta-blocker and thiazide diuretic combinations are available only with
your doctor's prescription, in the following dosage forms:
Oral
-
Atenolol and chlorthalidone
-
Tablets (U.S. and Canada)
-
Bisoprolol and hydrochlorothiazide
-
Metoprolol and hydrochlorothiazide
-
Nadolol and bendroflumethiazide
-
Tablets (U.S. and Canada)
-
Pindolol and hydrochlorothiazide
-
Propranolol and hydrochlorothiazide
-
Extended-release capsules (U.S.)
-
Tablets (U.S. and Canada)
-
Timolol and hydrochlorothiazide
-
Tablets (U.S. and Canada)
Brand NamesSome commonly used brand names are:
In the U.S.—
- Corzide 40/5 4
- Corzide 80/5 4
- Inderide 6
- Inderide LA 6
- Lopressor HCT 3
- Tenoretic 50 1
- Tenoretic 100 1
- Timolide 10-25 7
- Ziac 2
In Canada—
- Corzide 4
- Inderide 6
- Tenoretic 1
- Timolide 7
- Viskazide 5
|
Note:
|
For quick reference, the following beta-adrenergic blocking agents
and thiazide diuretics are numbered to match the corresponding brand names. |
| This information applies to the following medicines: |
| 1. |
Atenolol and Chlorthalidone (a-TEN-oh-lole and klor-THAL-i-doan)‡ |
| 2. |
Bisoprolol and Hydrochlorothiazide (bis-OH-proe-lol and hye-droe-klor-oh-THYE-a-zide)† |
| 3. |
Metoprolol and Hydrochlorothiazide (me-TOE-proe-lole and hye-droe-klor-oh-THYE-a-zide)† |
| 4. |
Nadolol and Bendroflumethiazide (NAY-doe-lole and ben-droe-floo-meth-EYE-a-zide) |
| 5. |
Pindolol and Hydrochlorothiazide (PIN-doe-lole and hye-droe-klor-oh-THYE-a-zide)* |
| 6. |
Propranolol and Hydrochlorothiazide (proe-PRAN-oh-lole and hye-droe-klor-oh-THYE-a-zide)‡ |
| 7. |
Timolol and Hydrochlorothiazide (TIM-oh-lole and hye-droe-klor-oh-THYE-a-zide) |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| ‡ Generic name product may be available in the U.S. |
|
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