Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and check with your doctor immediately if any of the following side effects occur:

More common

Diarrhea (moderately severe [four to six stools a day more than usual, or at night]); pain, blistering, peeling, redness, or swelling of palms of hands and/or bottoms of feet (severe enough to interfere with normal activities); pain and redness, swelling, or sores or ulcers in your mouth or on your lips (severe enough to interfere with eating)

Less common

Nausea (severe, accompanied by loss of appetite); vomiting (severe [occurring two times or more in 24 hours])

Also check with your doctor immediately if any of the following side effects occur:

Less common or rare

Abdominal or stomach cramping or pain (severe); blood in urine or stools; bloody or black, tarry stools; chest pain; constipation (severe); cough or hoarseness (accompanied by fever or chills); difficulty in swallowing or pain in back of throat or chest when swallowing; fast or irregular heartbeat; fever or chills; hot, red skin on feet or legs; lower back or side pain (accompanied by fever or chills); painful or difficult urination (accompanied by fever or chills); painful, swollen feet or legs; pain, tenderness, and/or swelling in upper abdominal (stomach) area; pinpoint red spots on skin; shortness of breath, troubled breathing, tightness in chest, and/or wheezing; sneezing, sore throat, and/or stuffy nose; tiredness or weakness (severe); unusual bleeding or bruising; vomiting blood or material that looks like coffee grounds; white spots in mouth or throat; yellow eyes or skin

Also, check with your doctor as soon as possible if any of the following side effects occur:

More common

Abdominal or stomach pain (mild or moderate); blistering, peeling, redness, and/or swelling of palms of hands or bottoms of feet (not severe enough to interfere with daily activities); diarrhea (mild [fewer than four stools a day more than usual]); numbness, pain, tingling, or other unusual sensations in palms of hands or bottoms of feet; pain and redness, swelling, or sores or ulcers in your mouth or on your lips (not severe enough to interfere with eating); unusual tiredness or weakness (mild or moderate)

Less common or rare

Clumsiness or unsteadiness; dark urine; decrease or increase in blood pressure; light-colored stools; problems with coordination; skin rash or itching; swelling of face, fingers, feet, or lower legs; swollen glands; unexplained nosebleeds

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Constipation (mild or moderate); loss of appetite (not due to nausea); nausea (not accompanied by loss of appetite); vomiting (mild [once a day or less])

Less common or rare

Changes in fingernails or toenails; dizziness; headache; heartburn; increased sensitivity of skin to sunlight; muscle pain; pain and redness of skin at place of earlier radiation (x-ray) treatment; red, sore eyes; trouble in sleeping

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.