Proper Use of This Medicine

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Glyburide and metformin combination should be taken with meals to help reduce the gastrointestinal side effects that may occur during the first few weeks of treatment.

Dosing—The dose of the glyburide and metformin combination will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of glyburide and metformin. If your dose is different, do not change it unless your doctor tells you to do so.

• For oral dosage form (tablets):
  • For type 2 diabetes:
    • For first-time treatment:
      • Adults: At first, 1.25 milligrams (mg) of glyburide and 250 mg of metformin one or two times a day with meals. Then, your doctor may increase your dose a little at a time every two weeks until your blood sugar is controlled.
      • Children: Use and dose must be determined by your doctor.
    • For patients previously treated with a sulfonylurea antidiabetic agent and/or metformin:
      • Adults: At first, 2.5 mg of glyburide and 500 mg of metformin or 5 mg of glyburide and 500 mg of metformin two times a day, with the morning and evening meals. Then, your doctor may increase your dose a little at a time until your blood sugar is controlled.
      • Children: Use and dose must be determined by your doctor.

Storage—To store this medicine:

• Keep out of the reach of children.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Keep the medicine from freezing. Do not refrigerate.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.