Proper Use of This Medicine

A paper with information about lopinavir and ritonavir will be given to you with your filled prescription. Read this paper carefully and ask your health care professional if you need additional information or explanation.

It is important that lopinavir and ritonavir be taken with food.

For oral solution dosage form, use calibrated dosing syringe to measure dose.

Take this medicine exactly as directed by your doctor. Do not take it more often and do not take it for a longer time than your doctor ordered. Also, do not stop taking this medicine without checking with your doctor first.

Dosing—The dose of lopinavir and ritonavir will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of lopinavir and ritonavir. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules or milliliters (mL) of lopinavir and ritonavir that you take depends on the strength of the medicine.

• For oral dosage form (capsules):
  • For treatment of HIV infection:
    • Adults: 400 milligrams (mg) of lopinavir and 100 mg of ritonavir (3 capsules) twice a day with food.
    • Children: This dosage form is usually not used for children. Please refer to the oral solution dosage form.
• For oral dosage form (oral solution):
  • For treatment of HIV infection:
    • Adults and adolescents: 400 mg of lopinavir and 100 mg of ritonavir (5 milliliters [mL]) twice a day with food.
    • Children 6 months to 12 years of age: Dose is based on body weight and must be determined by your doctor.
    • Children less than 6 months of age: Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store in the refrigerator. However, keep the medicine from freezing.
• Avoid high heat.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.