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You are here : Healthopedia.com > Drugs & Medications > Detailed Drug Information (USP DI) > Phenothiazines

Phenothiazines (Systemic)

Description and Brand Names | Before Using | Proper Use | Precautions | Side Effects | Additional Information


Category
  • Analgesic—Methotrimeprazine
  • Anesthetic adjunct—Chlorpromazine; Methotrimeprazine, intravenous
  • Antidyskinetic, Huntington's chorea—Chlorpromazine; Thioridazine
  • Antiemetic—Chlorpromazine; Methotrimeprazine; Perphenazine; Prochlorperazine; Trifluoperazine; Triflupromazine
  • Antineuralgia adjunct—Fluphenazine
  • Antipsychotic—Chlorpromazine; Fluphenazine; Mesoridazine; Methotrimeprazine; Perphenazine; Pipotiazine; Prochlorperazine; Promazine; Thioproperazine; Thioridazine; Trifluoperazine; Triflupromazine
  • Antipsychotic adjunct—Pericyazine
  • Sedative—Chlorpromazine; Methotrimeprazine; Thioridazine
Description

Phenothiazines (FEE-noe-THYE-a-zeens) are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. Phenothiazines may also be used for other conditions as determined by your doctor.

Phenothiazines may cause unwanted, unattractive, and uncontrolled face or body movements that may not go away when you stop taking the medicine. They may also cause other serious unwanted effects. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Also, your doctor should look for early signs of these effects at regular visits. Your doctor may be able to stop or decrease some unwanted effects, if they do occur, by changing your dose or by making other changes in your treatment.

Phenothiazines are available only with your doctor's prescription in the following dosage forms:

    Oral
  • Chlorpromazine
    • Extended-release capsules (U.S.)
    • Oral concentrate (U.S. and Canada)
    • Syrup (U.S. and Canada)
    • Tablets (U.S. and Canada)
  • Fluphenazine
    • Elixir (U.S. and Canada)
    • Oral solution (U.S.)
    • Tablets (U.S. and Canada)
  • Mesoridazine
    • Oral solution (U.S.)
    • Tablets (U.S. and Canada)
  • Methotrimeprazine
    • Oral solution (Canada)
    • Tablets (Canada)
  • Pericyazine
    • Capsules (Canada)
    • Oral solution (Canada)
  • Perphenazine
    • Oral solution (U.S. and Canada)
    • Tablets (U.S. and Canada)
  • Prochlorperazine
    • Extended-release capsules (U.S.)
    • Oral solution (U.S. and Canada)
    • Tablets (U.S. and Canada)
  • Thioproperazine
    • Tablets (Canada)
  • Thioridazine
    • Oral solution (U.S. and Canada)
    • Oral suspension (U.S. and Canada)
    • Tablets (U.S. and Canada)
  • Trifluoperazine
    • Syrup (U.S. and Canada)
    • Tablets (U.S. and Canada)
    Parenteral
  • Chlorpromazine
    • Injection (U.S. and Canada)
  • Fluphenazine
    • Injection (U.S. and Canada)
  • Mesoridazine
    • Injection (U.S.)
  • Methotrimeprazine
    • Injection (Canada)
  • Perphenazine
    • Injection (U.S.)
  • Pipotiazine
    • Injection (Canada)
  • Prochlorperazine
    • Injection (U.S. and Canada)
  • Promazine
    • Injection (Canada)
  • Trifluoperazine
    • Injection (U.S.)
  • Triflupromazine
    • Injection (U.S.)
    Rectal
  • Chlorpromazine
    • Suppositories (U.S. and Canada)
  • Prochlorperazine
    • Suppositories (U.S. and Canada)

Brand Names

Some commonly used brand names are:

In the U.S.—

  • Chlorpromazine Hydrochloride Intensol 1
  • Compazine 8
  • Compazine Spansule 8
  • Mellaril 11
  • Mellaril Concentrate 11
  • Mellaril-S 11
  • Permitil 2
  • Permitil Concentrate 2
  • Prolixin 2
  • Prolixin Concentrate 2
  • Prolixin Decanoate 2
  • Prolixin Enanthate 2
  • Serentil 3
  • Serentil Concentrate 3
  • Stelazine 12
  • Stelazine Concentrate 12
  • Thorazine 1
  • Thorazine Spansule 1
  • Trilafon 6
  • Trilafon Concentrate 6
  • Vesprin 13

In Canada—

  • Apo-Fluphenazine 2
  • Apo-Perphenazine 6
  • Apo-Thioridazine 11
  • Apo-Trifluoperazine 12
  • Chlorpromanyl-20 1
  • Chlorpromanyl-40 1
  • Largactil 1
  • Largactil Liquid 1
  • Largactil Oral Drops 1
  • Majeptil 10
  • Mellaril 11
  • Modecate 2
  • Modecate Concentrate 2
  • Moditen Enanthate 2
  • Moditen HCl 2
  • Neuleptil 5
  • Novo-Chlorpromazine 1
  • Novo-Trifluzine 12
  • Novo-Ridazine 11
  • Nozinan 4
  • Nozinan Liquid 4
  • Nozinan Oral Drops 4
  • Nu-Prochlor 8
  • Piportil L 4 7
  • PMS Fluphenazine 2
  • PMS Perphenazine 6
  • PMS Prochlorperazine 8
  • PMS Thioridazine 11
  • PMS Trifluoperazine 12
  • Serentil 3
  • Stelazine 12
  • Stemetil 8
  • Stemetil Liquid 8

Note:

For quick reference, the following phenothiazines are numbered to match the corresponding brand names.

This information applies to the following medicines:
1. Chlorpromazine (klor-PROE-ma-zeen)‡§
2. Fluphenazine (floo-FEN-a-zeen)‡§
3. Mesoridazine (mez-oh-RID-a-zeen)
4. Methotrimeprazine (meth-oh-trye-MEP-ra-zeen)*
5. Pericyazine (pair-ee-SYE-a-zeen)*
6. Perphenazine (per-FEN-a-zeen)‡§
7. Pipotiazine (pip-oh-TYE-a-zeen)*
8. Prochlorperazine (proe-klor-PAIR-a-zeen)‡§
9. Promazine (PROE-ma-zeen)*§
10. Thioproperazine (thye-oh-proe-PAIR-a-zeen)*
11. Thioridazine (thye-oh-RID-a-zeen)‡
12. Trifluoperazine (trye-floo-oh-PAIR-a-zeen)‡§
13. Triflupromazine (trye-floo-PROE-ma-zeen)†

Note:

This information does not apply to Ethopropazine,Promethazine, Propiomazine, and Trimeprazine.
* Not commercially available in the U.S.
† Not commercially available in Canada
‡ Generic name product may be available in the U.S.
§ Generic name product may be available in Canada

   

Next section

   

Phenothiazines: Before Using

Date Revised: 12/18/2003






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Page Last Updated: 6th April, 2009