Amifostine (Injection)

Amifostine (am-i-FOS-teen)

Protects the bladder from harmful effects caused by some anti-cancer medicines (chemotherapy). Also protects the saliva glands during some types of radiation therapy.

Brand Name(s):

Ethyol
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to amifostine.

How to Use This Medicine:

Injectable

• This medicine, like all medicines used to treat cancer, is very strong. Make sure you understand why you are getting it and what the risks and benefits of treatment are. It is important for you to work closely with your doctor.
• You will receive this medicine while you are in a hospital or chemotherapy treatment center.
• This medicine is given before chemotherapy or radiation therapy. You may also receive other medicines to help prevent nausea and vomiting.
• Your medicine will be given directly into a vein, usually in your arm or chest. This is called intravenous (in-tra-VEEN-us), or IV.
• You will be watched closely for unwanted side effects while you are receiving this medicine.
• Drink plenty of fluids during the 24 hours before receiving this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are taking diuretics (water pills) or any other medicines for high blood pressure. Your doctor may tell you not to take these medicines for 24 hours before receiving amifostine.

Warnings While Using This Medicine:

• If you are pregnant or breastfeeding, talk to your doctor before you start your treatments.
• Be sure your doctor knows if you have a history of heart disease, stroke, or TIA (transient ischemic attack).
• This medicine causes nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
• Your doctor may want to check your blood. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Feeling faint
• Rash, hives, blisters, or peeling of skin
• Severe nausea and/or vomiting
• Sudden dizziness or lightheadedness
• Trouble breathing or swallowing

If you notice these less serious side effects, talk with your doctor:

• Fever or chills
• Sleepiness

If you notice other side effects that you think are caused by this medicine, tell your doctor.