Denileukin Diftitox (Injection)

Denileukin Diftitox (de-ni-LOO-kin DIF-ti-toks)

Treats a type of cancer called cutaneous T-cell lymphoma. This is a cancer that occurs inside the body, but can cause problems on the skin

Brand Name(s):

Ontak
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to denileukin diftitox, diphtheria toxin, or interleukin-2.

How to Use This Medicine:

Injectable

• This medicine, like all medicines used to treat cancer, is very strong. Make sure you understand why you are receiving this medicine and what the risks and benefits of treatment are. It is important for you to work closely with your doctor.
• You will receive this medicine in a hospital or cancer treatment center.
• An intravenous (in-tra-VEEN-us) or IV injection is given through a tube put in one of your veins, usually in your arm, wrist, hand, or sometimes in your chest.
• A nurse or other caregiver trained to give injections will give your treatment.
• The medicine must be injected slowly, so your IV tube will need to stay in place for up to 30 minutes.
• This medicine is usually given every day for 5 days. This 5-day treatment is given again every 21 days for several months, or until your body responds to the medicine.

If a dose is missed:

• This medicine needs to be given on a regular schedule. If you miss a dose, call your doctor or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

• If you are pregnant or breastfeeding, talk to your doctor before receiving this medicine.
• Before receiving this medicine, tell your doctor if you have heart or lung disease.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Aching calf or thigh pain
• Chest pain
• Dizziness when getting up from a sitting or lying down position
• Skin rash or itching
• Shortness of breath
• Swelling in the hands, arms, legs, or feet
• Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

• Diarrhea
• Fever, chills or sore throat
• Nausea and vomiting

If you notice other side effects that you think are caused by this medicine, tell your doctor.