Dinoprostone (Vaginal)

Dinoprostone (dye-noe-PROST-one)

Helps dilate the opening of the uterus (cervix) in a pregnant woman. Belongs to a class of drugs called prostaglandins.

Brand Name(s):

Cervidil, Prostin E2, Prepidil
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to dinoprostone.

How to Use This Medicine:

Insert, Suppository, Gel/Jelly

• You will receive this medicine in a hospital or clinic, unless otherwise directed by your doctor.
• A nurse or doctor will insert this medicine into your vagina so that the medicine comes into contact with your cervix. The nurse or doctor will need to use a speculum to insert the gel.
• The gel or suppository should be brought to room temperature just before being placed in the vagina.
• You will need to lie on your back for up to 2 hours after the insert is put in place. You will need to lie on your back for up to 30 minutes after the gel or suppository is inserted.
• The insert will be removed 12 hours after it was inserted or when active labor begins.

How to Store and Dispose of This Medicine:

• If you use this medicine at home, store the insert or suppository in a freezer, away from heat and light until you are ready to insert it.
• Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Let your doctor know if you are using any other vaginal medicines.

Warnings While Using This Medicine:

• Tell your doctor if you have had any unusual vaginal bleeding, if you have had 6 or more full-term pregnancies, or if you have pelvic inflammatory disease.
• Let your doctor know if you have heart disease, liver disease, kidney problems, asthma, lung disease, or a history of bleeding disorders, diabetes, glaucoma, or seizures.
• If you are breastfeeding, talk to your doctor before using this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Chest pain or tightness
• Fast, slow, or irregular heartbeat
• Labor pains
• Rash or itching
• Trouble breathing or swallowing

If you notice these less serious side effects, talk with your doctor:

• Back pain or stomach pain
• Diarrhea, nausea, or vomiting
• Fever or chills
• Headache
• Warm feeling in the vagina

If you notice other side effects that you think are caused by this medicine, tell your doctor.