Leucovorin (By Mouth)

Leucovorin (loo-koe-VOR-in)

Prevents and treats side effects caused by certain kinds of medicines such as methotrexate (an anti-cancer medicine) or pyrimethamine (used to treat infections).

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to leucovorin.

How to Use This Medicine:

Tablet

• Your doctor will tell you how much medicine to take and how often. Make sure you understand your doctor's orders.
• If you vomit right after you take this medicine, tell your doctor.

If a dose is missed:

• This medicine needs to be given on a regular schedule. If you miss a dose, call your doctor for instructions.

How to Store and Dispose of This Medicine:

• Store the tablets at room temperature, away from heat, moisture, and direct light.
• Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are also taking fluorouracil, phenobarbital, phenytoin (Dilantin®), or primidone (Mysoline®).

Warnings While Using This Medicine:

• If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
• Before taking this medicine, make sure your doctor knows if you have anemia.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Wheezing or trouble breathing
• Skin rash, itching, or hives
• Swelling in the lips, face, or tongue

If you notice other side effects that you think are caused by this medicine, tell your doctor.