Piperacillin/Tazobactam (Injection)

Piperacillin (pi-PER-a-sil-in), Tazobactam (ta-zoe-BAK-tam)

Treats infections. Belongs to a class of drugs called penicillin antibiotics.

Brand Name(s):

Zosyn
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to piperacillin or any penicillin medicine.

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given.
• An IM injection is a shot given in your muscle (upper arm, thigh, buttocks). An IV infusion is medicine that is put directly into your body through one of your veins.
• This medicine should be given by a person trained to give IV or IM medicine, such as a nurse. Sometimes you, a family member, or friend can be taught to give your medicine.
• If you are receiving IV medicine, check the bag to make sure there are no leaks. Also make sure the solution is clear.

If a dose is missed:

• This medicine needs to be given on a regular schedule. Take the missed dose as soon as you remember, and take the rest of the doses for the day at regularly spaced time intervals.
• If you miss more than one dose, call your doctor for instructions.

How to Store and Dispose of This Medicine:

• Store the medicine in a refrigerator. Do not freeze. Take it out of the refrigerator an hour before the time for your next dose and allow it to warm to room temperature in a clean, dry place.
• If you see particles in the solution, You should not use it.
• If you have your treatments at home, you should be given a special container for the used needles. Keep it where children or pets cannot reach it.
• Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are taking probenecid before you take this medicine.
• Birth control pills may not work as well while taking piperacillin/tazobactam. Use another kind of birth control while you are taking this medicine.

Warnings While Using This Medicine:

• Make sure your doctor knows if you have ever had an allergic reaction to any cephalosporin antibiotic such as Keflex® or Ceclor® before you take piperacillin/tazobactam.
• Make sure your doctor knows if you have mononucleosis (mono), stomach or intestinal disease, asthma, liver disease, hay fever, or other allergies before you take this medicine.
• If your infection does not improve, or if it gets worse while taking this medicine, talk to your doctor.
• If you have severe diarrhea while taking piperacillin/tazobactam, check with your doctor before taking medicine to stop the diarrhea.
• If you are pregnant or breastfeeding, talk to your doctor before taking piperacillin/tazobactam.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Rash or hives
• Blistering or peeling skin
• Swelling of the face, throat, or lips
• Wheezing or trouble breathing
• Severe diarrhea (watery or bloody)
• Swelling, pain, or redness near where your IV is located

If you notice these less serious side effects, talk with your doctor:

• Mild diarrhea or nausea
• Sore mouth or tongue
• Vaginal itching or discharge
• Pain where your IM shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor.