What are the treatments for the disease?

Often, a person with no symptoms is not treated. A person who does have symptoms is usually treated with medicines. Examples are nonsteroidal anti-inflammatory medicines such as ibuprofen. Medicines may be used to inhibit bone destruction and reduce pain in people with more severe disease. These include calcitonin and biphosphonates. Biphosphonates include risedronate, alendronate, and pamidronate.

Other treatments that are used for Paget disease include:

Long-term treatment may be needed if the disease is severe, especially if the person has nervous system problems. Adaptive equipment, such as canes and crutches, may be needed. Physical therapy may be ordered to maintain mobility and function. Surgery may be required for severely affected bones.

What are the side effects of the treatments?

All medicines can have side effects, including allergic reactions. For example, calcitonin may cause nausea and skin flushing. Herbal remedies may interfere with prescription medicines and cause bleeding problems. Surgery can cause bleeding, infection, and allergic reactions to anesthesia.

What happens after treatment for the disease?

Paget disease often requires lifelong treatment. If the symptoms go away, treatment may be stopped for a while.

How is the disease monitored?

A person with Paget disease will have regular visits with the healthcare provider. Blood and urine tests may also be performed. Any new or worsening symptoms should be reported to the provider.