Poststreptococcal glomerulonephritis (PSGN) is a type of kidney inflammation. It is caused by a reaction to an infection with certain strains of bacteria called Streptococcus.

What is going on in the body?

Poststreptococcal glomerulonephritis mostly affects children, who are prone to Streptococcus infections. These bacteria are a common cause of sore throat, sometimes called strep throat. They can also cause skin infections known as impetigo. When a person has one of these infections, the immune system can sometimes react abnormally. This reaction can cause inflammation and even damage in the kidneys. It is not known why this occurs. Most people recover from PSGN and have no long-term effects. Some, however, get permanent kidney failure from PSGN.

What are the causes and risks of the disease?

PSGN is caused by an infection with certain strains of Streptococcus bacteria. When the infection is in the throat, it's called pharyngitis. When it's in the skin, it's often called impetigo. Children between 4 and 10 years old are most commonly affected. Males are more likely to be affected than females. Adults with PSGN usually have more serious kidney inflammation than children and are less likely to have a full recovery.